Within five months, we were able to prepare a complete benefit dossier for the client. A randomised controlled trial (RCT) provided the basis for the presentation of the benefits and additional benefits. The control arm of this RCT represented the appropriate comparator as determined by the G-BA only for one subpopulation. For the other subpopulation an adjusted indirect comparison according to Bucher had to be calculated. We performed all analyses and prepared the complete benefit dossier within the allocated timeframe, which we were able to ensure through time-efficient review cycles and absolute prioritisation of this project. We also supported our client in the subsequent written statement and hearings.